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KMID : 1140120110160040387
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Cancer Prevention Research
2011 Volume.16 No. 4 p.387 ~ p.394
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Antioxidative Activity and Protective Effect from Gastric Cancer of Korean Folk Plants
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Choi Ji-Myung
Choi Ji-Yeon
Kim Hye-Min
Choi Kyung
Ku Ja-Jung
Park Kwang-Woo
Lee Sang-Hyun
Cho Eun-Ju
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Abstract
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The antioxidative activity and prevention effect from gastric cancer of Korean folk plants (KFPs) were investigated. The radical scavenging activities against 1,1-diphenyl-2-picrylhydrazyl (DPPH) and hydroxyl radical (ㆍOH) were measured. Among 52 KFPs, 21 and 52 plants at 100μg/ml showed over 80% scavenging activity of DPPH and ㆍOH, respectively. In particular, Mukdenia rossi (Oliver) Koidzumi showed the strongest radical scavenging activity against DPPH and ㆍOH. In addition, microbial inhibition activity against Helicobacter pylori (H. pylori) and growth inhibitory effects in human gastric adenocarcinoma cells (AGS) were investigated. The treatment of MeOH extracts from 9 plants at the concentration of 10μg/30μl showed strong antimicrobial activity (clear zone ＞13 mm) against H. pylori and 8 plants inhibited over 60% growth of AGS cells at 100μg/ml. Especially, Hemistepta lyrata Bunge and Aster incisus Fisch scavenged radical and inhibited growth of gastric cancer cells the most effectively, suggesting the promising novel resources for the prevention of degenerative diseases including gastric cancer.
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KEYWORD
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Korean folk plant, DPPH, Hydroxyl radical, Helicobacter pylori, AGS human adenocarcinoma cell
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